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A network of European scientists from academic and industry focused on developing innovative myeloid regulatory cell (MRC)-based immunotherapies.

INsTRuCT Consortium: Call for applications from Early Stage Researchers for 15 Doctoral (PhD) Training Positions in Basic, Translational and Computational Immunotherapy


Original Call page on Euraxess
Open Position ESR12 | Deadline 15th August 2021

INsTRuCT website


INsTRuCT is an Innovative Training Network (ITN) funded by the European Union Horizon 2020 Programme.
The INsTRuCT Consortium is a research network of leading European scientists from academia and industry focused on fundamental research and clinical translation of myeloid regulatory cell (MRC)-based immunotherapies. A total of 15 doctoral research projects (PhD projects) for Early Stage Researchers (ESR) are offered across 13 institutes in Europe. Research topics range from fundamental to translational science, all at the forefront in the field of MRC-based immunotherapies. Successful applicants will also receive expert training in basic immunological research, preclinical pharmacological development, manufacturing processes, clinical trial design, healthcare economics, ethics and marketing. The interaction of biologists, computational scientists, physicians and engineers is central to INsTRuCT and will challenge ESR to explore complex issues in bench-to-bedside research from different perspectives. Graduates of INsTRuCT will be well-prepared to enter the workplace with an innovative and beyond state-of-the-art view on fundamental and translational science of cell-based therapies that will accelerate the future of the field.


Participating in INsTRuCT offers early stage researchers many unique opportunities, including:

  • A project as Marie Skłodowska Curie trainee in one of the participating institutions with the intention of receiving a doctoral degree (PhD).

  • State-of-the art, exciting research in an international consortium with highly integrated research projects.

  • Expert training in preclinical and clinical development of cell-based medicinal products.

  • At least two months of research training in the lab of another consortium member, mostly in a different EU country than the country where most of the project will take place.

  • Training in both academic and commercial research environments.

  • Salary according to EU guidelines for Marie Skłodowska Curie trainees, including mobility payments and family allowances where applicable.

Eligible candidates must:

  • hold a Master’s degree or equivalent in a field of science relevant to their chosen project (see below)

  • demonstrate a history of academic excellence

  • demonstrate an affinity for Basic Immunology, Computational Biology, bio(medical/process)engineering or translational research

  • speak and write fluently in English

  • have less than 4 years’ previous research experience and not hold a doctoral (PhD) title

  • have not been resident in the country where the host institution is located for more than 12 months in the 3 years before recruitment

  • be available for a personal interview at the INsTRuCT recruitment meeting in Barcelona, 23rd - 25th March 2020

  • be available to start their project no later than 1st September, 2020

Application Process

INsTRuCT will select ESR through a 2-step recruitment process. Candidates should submit their application for their top two or three preferred research projects. Applications (in English) should include a CV, a Letter of Motivation and a Letter of Recommendation from two appropriate referees. The closing date for applications is 31st January, 2020. Application documents should be sent by email to Mrs. Christine Bayer, Project Administrator (christine.bayer@ukr.de) and the relevant project supervisors by email (see individual project descriptions). Applicants are advised to familiarise themselves thoroughly with projects for which they apply and be ready to answer questions on their chosen topics. After reviewing all project applications, supervisors of individual projects will contact selected applicants to organise an initial screening interview by telephone or videoconferencing. The most promising candidates will then be invited to a personal interview in a recruitment meeting of the whole consortium in Barcelona on 23rd - 25th March, 2020. Approximately half of those interviewed in the second round will be offered a position.

Research projects offered by INsTRuCT
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ESR Project Title Subject Area Primary Supervisor Institution EU State
1 Metabolic Programming of Human Monocyte Differentiation
Molecular Immunology ZASLONA, Z. Trinity College Dublin IE
2 Mitochondrial and metabolic functions of tolerogenic myeloid cells
Molecular Immunology SAWITZKI, B. Berlin Charité DE
3 Engineered Tolerogenic Dendritic Cells for Ag-Specific Immunotherapy
Molecular Immunology GREGORI, S. Ospedale San Raffaele IT
4 Trained Immunity in Regulatory Macrophages
Molecular Immunology OCHANDO, J. University of Madrid ES
5 A data science approach to characterising myeloid regulatory cell therapies
Computational Biology LORD, P. - HILKENS, C. Newcastle University GB
6 Investigating molecular mechanisms of human autologous tolerogenic DC
Cellular Biology MOREAU, A. University of Nantes FR
7 Computational characterisation, classification and deconvolution of myeloid regulatory cells
Computational Biology REHLI, M. - SPANG, R. University Hospital Regensburg DE
8 Development of Pharmaceutical Release Processes for DC-based Therapy
GMP Manufacturing GERMERAAD, W. Cimaas BV NL
9 Personalized MRC-based therapy: Innovative strategies to improve efficacy
Computational Biology SANCHEZ FUEYO, A. King's College London GB
10 Development and validation of antigen-specific assays for T and B cell responses
Cellular Immunology BRINKE, A. - van HAM, M. Sanquin Blood Supply and University of Amsterdam NL
11 Development of an affordable & process for tolDC manufacturing
GMP Manufacturing COOLS, N. University of Antwerp BE
12 Classification of Human Myeloid Regulatory Cell Networks by Machine Learning
Computational Biology KOLLET, J. Miltenyi Biotec BV & Co. KG DE
13 Genes & pathways associated with the tolerogenic capacity of tolDC-VitD3
Molecular Immunology MARTINEZ, E. Institute of the Germans Trias i Pujol Foundation ES
14 Human Mreg-mediated conversion of naïve CD4+ T cells to iTreg
Cellular Immunology HUTCHINSON, J. University Hospital Regensburg DE
15 Route of delivery of tolerogenic dendritic cells
Clinical Immunology HILKENS, C. Newcastle University GB

Further Information

Interested candidates are advised to visit the INsTRuCT Consortium website for further information about projects. Questions about recruitment, training opportunities and the scientific activities of the INsTRuCT Consortium should be directed to Dr. James Hutchinson, Project Coordinator. INsTRuCT is committed to a fair, open, transparent and merit-based recruitment of researchers. To comply with Research Executive Agency policy, the INsTRuCT Consortium will retain copies of all documents submitted by all applicants at least until completion of the Project. In addition, INsTRuCT will retain copies of all evaluations made by project supervisors at every stage of the recruitment process. By submitting their application to INsTRuCT, candidates agree to their personal data being kept on record by University Hospital Regensburg and communicated to EU officials if demanded. The Data Protection Officer (DPO) at University Hospital Regensburg is Dr. Wolfgang Börner, who can be contacted by telephone on +49- (0)941 944 4420 or by sending an email to dsb@ukr.de.

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This project has received funding from the European Union’s
Horizon 2020 research and innovation programme under the
Marie Skłodowska-Curie grant agreement No 860003

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Last update: December 18, 2019

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